WDR5: The preeminent cellular multitasker

WDR5 is a highly conserved protein that has functions on and off chromatin. It nucleates assembly of multiple histone modifier complexes, is an important co-factor for MYC,  and has distinct functions in mitosis and ciliogenesis. Proteins that interact with WDR5 bind to one of two sites on the protein. We collaborate with Dr. Stephen Fesik to discover and validate small molecule inhibitors of both sites and to explore their therapeutic utility.

© Bill Tansey 2021